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目的：观察内皮素在原发性肾病综合征（ＰＮＳ）中的作用。方法：应用放射免疫法测定３１例ＰＮＳ患者和１０ 例正常人２４ ｈ 尿内皮素（ＵＥＴ）水平，并结合病理类型，血肌酐（Ｓｃｒ）、内生肌酐清除率（Ｃｃｒ）、尿视黄醇结合蛋白（ＲＢＰ）、２４ｈ 尿蛋白定量（２４ ｈＵＰＱ）、平均动脉压等指标进行分析。结果：ＰＮＳ患者ＵＥＴ水平显著高于正常人（Ｐ＜ ０．０１），且其水平与Ｓｃｒ、Ｃｃｒ、尿ＲＢＰ相关具显著性，但与病理类型、平均动脉压，２４ ｈ ＵＰＱ无相关性。结论：内皮素参与ＰＮＳ的发病过程；ＵＥＴ可作为反映ＰＮＳ患者肾小球功能和肾小管功能的敏感指标。
Objective: To observe the role of endothelin in primary nephrotic syndrome (PNS). Methods: The 24-hour urinary endothelin (UET) levels of 31 patients with PNS and 10 normal controls were measured by radioimmunoassay. The pathological types, serum creatinine (Scr), creatinine clearance rate (Ccr) RBP, 24h urine protein (24 hUPQ), mean arterial pressure and other indicators were analyzed. Results: The level of UET in PNS patients was significantly higher than that in normal people (P <0.01). The level of UET in PNS patients was significantly correlated with Scr, Ccr and urine RBP, but no correlation with pathological type, mean arterial pressure and 24 h UPQ. Conclusion: Endothelin is involved in the pathogenesis of PNS; UET can be used as a sensitive indicator of glomerular function and renal tubular function in patients with PNS.