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目的探讨甲氨喋呤宫颈多点注射联合米非司酮治疗未破裂输卵管妊娠的临床效果。方法有生育要求的160例患者被随机分为两组。观察组用甲氨喋呤1mg/kg加入5ml注射用水中宫颈多点注射,同时口服米非司酮150mg/d连用3d,对照组单次静脉注射甲氨喋呤1mg/kg,同法加服米非司酮。对照两组保守成功率,输卵管复通率及不良反应。结果两组保守成功率分别为91%和82%,输卵管复通率分别为78%和60%。差异有统计学意义(P<0.05),药物不良反应无差异。结论宫颈多点注射甲氨喋呤治疗未破裂型输卵管妊娠方便、有效、安全,可常规应用于临床。
Objective To investigate the clinical effect of methotrexate cervical multiple injection combined with mifepristone in the treatment of unruptured tubal pregnancy. Methods 160 patients with reproductive requirements were randomly assigned to two groups. Observation group with methotrexate 1mg / kg added 5ml injection of water in the cervix multi-point injection, while oral mifepristone 150mg / d with 3d, control group single intravenous methotrexate 1mg / kg, Mifepristone. Control two groups of conservative success rate, tubal recanalization rate and adverse reactions. Results The conservative success rates of the two groups were 91% and 82% respectively, and the tubal recurrence rates were 78% and 60% respectively. The difference was statistically significant (P <0.05), no difference in adverse drug reactions. Conclusion Cervical multi-injection of methotrexate in the treatment of unruptured tubal pregnancy is convenient, effective and safe and can be routinely used in clinical practice.