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目的探讨G蛋白偶联受体37与儿童孤独症的关系。方法采用病例对照研究方法对120例孤独症患儿进行问卷调查及G蛋白偶联受体37(GPR37)含量测定。结果病例组患儿血清GPR37表达水平为(12.27±1.73),对照组为(5.35±1.66),差异有统计学意义(t=31.61,P<0.001)。孤独症严重程度与血清GPR37表达水平均呈正相关(r=0.87,P<0.001)。结论儿童孤独症的发病可能与血清中GPR37表达有关,GPR37的表达水平可能作为孤独症严重程度的指示因子。
Objective To investigate the relationship between G protein-coupled receptor 37 and autism in children. Methods A case-control study was conducted in 120 children with autism to investigate the content of G-protein coupled receptor 37 (GPR37). Results The serum level of GPR37 was (12.27 ± 1.73) in the case group and (5.35 ± 1.66) in the control group, the difference was statistically significant (t = 31.61, P <0.001). Autism severity and serum GPR37 expression levels were positively correlated (r = 0.87, P <0.001). Conclusions The incidence of autism in children may be related to the expression of GPR37 in serum. The expression level of GPR37 may be used as an indicator of the severity of autism.