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本文对７７例口腔鳞癌的金属硫蛋白、增殖细胞核抗原（ＰＣＮＡ）的表达及其同患者预后的关系进行了研究。免疫组织化学染色结果显示：在正常和增生口腔上皮，金属硫蛋白在基底和基底旁细胞阳性，在上皮异常增生时阳性区扩大；在高分化鳞癌，金属硫蛋白阳性细胞位于癌巢周围，在低分化鳞癌则散在分布。上述金属硫蛋白分布特点与ＰＣＮＡ阳性细胞分布特点一致。金属硫蛋白阳性者术后复发率为４３．８％，阴性者为７．７％；化疗后复发率在阳性者为５９．３％，阴性者为５．５％。结果提示金属硫蛋白的表达与口腔鳞癌的细胞增殖及患者的预后有关。
In this paper, 77 cases of oral squamous cell carcinoma of the metallothionein, proliferating cell nuclear antigen (PCNA) expression and its relationship with the prognosis of the patients were studied. Immunohistochemical staining results showed that in normal and hyperplastic oral epithelium, metallothionein was positive in basal and basal cells and enlarged in epithelial dysplasia. In well-differentiated squamous cell carcinoma, metallothionein-positive cells were located around cancer nests, Poorly differentiated squamous cell carcinoma is scattered. The above-mentioned characteristics of metallothionein distribution and PCNA-positive cells are consistent. Methotrecipitin positive postoperative recurrence rate was 43.8%, the negative was 7.7%; after chemotherapy, the recurrence rate was 59.3% positive, negative, 5.5%. The results suggest that the expression of metallothionein and oral squamous cell carcinoma cell proliferation and prognosis.