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本文测定了80例连续服用国产低剂量Ⅰ号避孕片5～15年的健康农村妇女及78例同期应用宫内节育器妇女的脂类、脂蛋白及载脂蛋白AI(APO_(AI))、载脂蛋白B(APO_B)和过氧化脂质(LPO)水平。结果表明,长期服用低剂量OC_s 对健康妇女脂代谢远期作用明显。服药组TG、TC、HDL-C、APO_(AI)均显著高于对照而APO_B、LPO 水平则与对照组间无显著差异。特别是在30～39岁持续服药10年以上的妇女中,TC、HDL-C、APO_(AI)水平均同步升高,所以长期服用低剂量国产1号避孕片是否对心血管系统有不良影响尚待进一步研究。
In this paper, we measured the lipid, lipoprotein and apolipoprotein AI (APO_ (AI)) in 80 healthy rural women and 78 women with IUD at the same period. Apolipoprotein B (APO_B) and Lipid Peroxide (LPO) levels. The results showed that long-term use of low-dose OC_s long-term effect on lipid metabolism in healthy women significantly. The levels of TG, TC, HDL-C and APO_ (AI) in the medication group were significantly higher than those in the control group, while the levels of APO_B and LPO in the medication group were not significantly different from those in the control group. In particular, the levels of TC, HDL-C and APO_ (AI) in women aged 30 to 39 who have been on medication for more than 10 years are simultaneously increased, so whether long-term use of low-dose domestic contraceptive tablets No. 1 has an adverse effect on the cardiovascular system Yet to be further studied.