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为评估荧光原位杂交技术在检测自然流产组织染色体数目异常中的价值和意义,本研究应用FISH技术检测105例自然流产绒毛或胎儿肌肉组织的13、21、18、X、Y染色体的数目,结果显示染色体数目异常的样本为45例,占其中42.86%;数目异常率大于60%的样本为39例;数目异常率介于10%-60%的样本为6例,其中早期流产组织中染色体异常的为29例,占64.44%;常见的数目异常类型为常染色体三体和X单体。与传统的制备染色体技术相比,FISH技术具有快速准确、稳定性高等特点,可以为查明流产原因提供依据,具有很高的临床应用价值。
In order to evaluate the value and significance of fluorescence in situ hybridization in the detection of chromosome abnormalities in spontaneous abortion, FISH was used to detect the number of 13, 21, 18, X and Y chromosomes in 105 cases of spontaneous abortion or fetal muscle tissue, The results showed that there were 45 cases (42.86%) with abnormal chromosome number, 39 cases with more than 60% of the number of abnormal chromosomes, 6 cases (10% -60%) with abnormal chromosome number The abnormalities were 29 cases, accounting for 64.44%. The common types of abnormalities were autosomal trisomy and X monomer. Compared with the traditional preparation of chromosome technology, FISH technology has the characteristics of fast and accurate, high stability, which can provide the basis for identifying the causes of abortion and has high clinical value.