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目的:为了评价经大剂量左旋甲状腺素早期治疗的先天性甲状腺功能减退(CH)患儿入学时的认知能力和行为。试验设计:18例先天性甲状腺功能减退的患儿(CH:9例重度和9例中度,重、中度的诊断是依据膝盖骨的骨骺分别<或≥0.05cm2),从中位年龄14d起,接受中位剂量12.0μg/(kg·d)的左旋甲状腺素治疗。在5岁和9个月时用麦卡锡筛查量表和社会行为调
PURPOSE: To evaluate the cognitive ability and behavior of children with congenital hypothyroidism (CH) treated with high-dose levothyroxine early. TEST DESIGN: Eighteen children with congenital hypothyroidism (CH: 9 moderate and severe, and 9 moderate and severe diagnoses were based on the epiphysis of the kneecap respectively 0.05cm2). From a median age of 14 days, L-thyroxine was administered at a median dose of 12.0 μg / (kg · d). At age 5 and 9 months, the McCarthy screening scale and social behavior were adjusted