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目的:探讨平阳霉素碘油乳剂(PLE)与鱼肝油酸钠治疗肝血管瘤的疗效、安全性、患者的耐受程度。方法:每组随机选择各10例肝血管瘤患者,分别用PLE及鱼肝油酸钠栓塞,观察每组患者栓塞后的临床反应及表现,比较其栓塞效果。结果:1.用PLE栓塞组,患者术后一般发热3~7d,最高达38.1℃,术中有肝区憋胀,轻度疼痛,术后肝区疼痛较轻,均未使用止痛针剂。随访5个月,肿瘤平均缩小70%以上。2.用鱼肝油酸钠栓塞组,患者术后一般发热2~3d,最高者达38℃,术中即有肝区憋胀、巨痛,术后肝区疼痛剧烈,每个患者平均使用度冷丁200~300mg。随访5个月,肿瘤缩小72%以上。结论:笔者认为平阳霉素与鱼肝油酸钠对血管的硬化和肝血管瘤的治疗,疗效相当。但平阳霉素栓塞术后,临床反应较轻,痛苦小,患者更容易接受。
Objective: To investigate the efficacy, safety and tolerability of bleomycin lipiodol emulsion (PLE) and sodium morrhuate in the treatment of hepatic hemangiomas. Methods: Ten patients with hepatic hemangioma were randomly selected in each group. The patients were embolized with PLE and sodium morrhuate respectively. The clinical response and performance after embolization of each group were observed. The embolization effect was compared. Patients with PLE embolism group, the general postoperative fever 3 ~ 7d, up to 38.1 ℃, intraoperative liver swelling, mild pain, postoperative liver pain less, no use of analgesic injection. After 5 months of follow-up, the tumors were reduced by more than 70% on average. 2. With sodium cod liver oil embolization group, the patients after the general fever 2 ~ 3d, the highest of 38 ℃, intraoperative liver swelling, pain, severe liver pain, the average per patient using cold Ding 200 ~ 300mg. Follow-up 5 months, the tumor narrowed more than 72%. Conclusion: I believe that Pingyangmycin and sodium morrhuate on vascular sclerosis and Hepatic Hemangioma treatment, the effect is quite. However, after Pingyangmycin embolization, the clinical response is mild, less painful, patients are more likely to accept.