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目的观察参芪扶正注射液联合FOLFOX4治疗晚期胃癌的疗效及其不良反应。方法选取2009年1月～2012年6月在上海市奉贤中心医院就诊的Ⅲ～Ⅳ期初治晚期胃癌患者70例,将患者随机分为观察组和对照组,两组均为35例。对照组予以FOLFOX4方案治疗,观察组在对照组的基础上予以参芪扶正注射液治疗。观察两组治疗前后白细胞(WBC)、淋巴细胞(Lym)、血小板计数(PLT)和生存质量评分的变化及其疗效。结果观察组的近期疾病控制率为88.57%,生活质量改善率为71.43%,而对照组分别为65.71%和42.86%,观察组的疗效优于对照组,差异有统计学意义(P<0.05)。治疗后两组的WBC、Lym、PLT和生存质量评分较治疗前明显降低(P<0.01),而观察组降低水平更为明显,差异有高度统计学意义(P<0.01)。观察组的不良反应(如恶心、呕吐、腹泻和肝肾功能)发生率较对照组明显降低,差异有统计学意义(P<0.05)。结论参芪扶正注射液联合FOLFOX4化疗可提高晚期胃癌患者的疗效及生活质量,同时可减轻化疗毒副作用。
Objective To observe the curative effect and adverse reactions of Shenqi Fuzheng injection combined with FOLFOX4 in the treatment of advanced gastric cancer. Methods Seventy patients with stage Ⅲ ~ Ⅳ advanced gastric cancer who were treated in Shanghai Fengxian Central Hospital from January 2009 to June 2012 were selected and randomly divided into observation group and control group, with 35 cases in both groups. The control group was treated with FOLFOX4 regimen, and the observation group was given Shenqi Fuzheng injection on the basis of the control group. The changes of WBC, Lym, PLT and quality of life before and after treatment were observed and the curative effects were observed. Results The rate of disease control in the observation group was 88.57% and the quality of life improvement rate was 71.43% in the observation group compared with 65.71% and 42.86% in the control group respectively. The observation group had better curative effect than the control group (P <0.05) . After treatment, the WBC, Lym, PLT and quality of life scores of two groups were significantly lower than those before treatment (P <0.01), while the observation group was more obvious, the difference was highly statistically significant (P <0.01). Adverse reactions (such as nausea, vomiting, diarrhea and liver and kidney function) in observation group were significantly lower than those in control group (P <0.05). Conclusion Shenqi Fuzheng injection combined with FOLFOX4 chemotherapy can improve the efficacy and quality of life of patients with advanced gastric cancer, and can reduce the side effects of chemotherapy.