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目的:探讨趋化因子CXCL10在儿童自身免疫性甲状腺炎(HT)中的作用机制和病程不同阶段的变化。方法:收集儿童和青少年HT53例和30例正常对照,应用ELISA方法测定两组血清CXCL10的水平并比较二者差异;比较病程不同阶段的HT的血清CXCL10的水平;测定儿童HT病人的甲状腺功能(FT3,FT4,sTSH)及甲状腺自身抗体水平(TGAb,TMAb,TRAb,TSI),应用spearman相关分析方法分析HT患儿的FT3,FT4,sTSH,TGAb,TMAb,TRAb,TSI这些指标与血清CXCL10水平的相关性。结果:血清CXCL10的水平在儿童HT比正常对照组升高(P<0.05);血清CXCL10的水平在儿童HT发病初期及未缓解期高于缓解期和正常对照组,有统计学意义。在HT组血清CXCL10的水平与sTSH呈正相关(P<0.01),与FT3、FT4、TGAb、TMAb、TRAb、TSI无相关性。结论:CXCL10在儿童HT的发病初期起重要作用,在儿童HT病程中存在着动态变化,研究CXCL10可为儿童HT的治疗开辟一条新的途径。
Objective: To investigate the mechanism of CXCL10 in children with autoimmune thyroiditis (HT) and the different stages of the disease. Methods: HT53 cases and 30 normal controls were collected from children and adolescents. Serum levels of CXCL10 were measured by ELISA. The levels of serum CXCL10 in different stages of the disease were compared. Thyroid function was measured in children with HT FT3, FT4, sTSH and thyroid autoantibodies (TGAb, TMAb, TRAb, TSI) were detected by spearman correlation analysis. The levels of FT3, FT4, sTSH, TGAb, Relevance. Results: The level of serum CXCL10 was higher in children with HT than that in normal controls (P <0.05). The level of serum CXCL10 was higher in children with early-onset HT and non-remission than those in remission and normal controls. The level of serum CXCL10 in HT group was positively correlated with sTSH (P <0.01), but not with FT3, FT4, TGAb, TMAb, TRAb and TSI. CONCLUSION: CXCL10 plays an important role in the early stage of HT in children, and there is a dynamic change in the course of childhood HT. CXCL10 may open up a new way for the treatment of HT in children.