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高脂血症是威胁人类健康的主要疾病之一，它不仅是一个独立的疾病还是高血压、高血糖、心血管疾病等的重要危险因素。中医痰证是高脂血症的主要证候之一，而微 RNA（ miRNA）－33、miR－122、miR－370、miR－378／378*、miR－27、miR－613等miRNA在脂质代谢中的重要调控作用也已得到证实。故以miRNA为出发点对脂质代谢的调控进行研究，为揭示中医痰证的病理机制提供新的思路，并为有效干预高脂血症痰证提供新靶点。“,”Hyperlipidemia is one of the main diseases that threaten the health of human , which is not only an independent disease,but also one of the important risk factors of hypertension,hyperglycemia,cardio-vascular diseases.Phlegm syndrome is one of the main syndromes of hyperlipidemia and the important regula-tory role of microRNA ( miRNA )-33, miR-122, miR-370, miR-378/378*, miR-27, miR-613 and other miRNA in lipid metabolism has been confirmed.Therefore,the study with miRNA as a starting point for the regulation of lipid metabolism,can provide new ideas for revealing the pathogenesis of phlegm syndrome,and provides new targets for the effective intervention to hyperlipidemia phlegm syndrome .