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目的探讨经蝶入路治疗垂体腺瘤临床意义。方法2000年9月～2008年9月共收治垂体腺瘤患者63例,术前均进行垂体冠状CT重建、MRI动态增强扫描,内分泌学检查。所有患者均经单鼻孔蝶窦入路显微手术肿瘤切除。随访3～36个月。结果肿瘤全切51例,次全切8例,部分切除4例。术后症状及内分泌检查改善60例,5例出现并发症,包括鼻黏膜感染,一过性脑脊液鼻漏,垂体功能低下。4例1年后复发。结论经蝶手术治疗垂体腺瘤创伤小,操作简单,安全,肿瘤切除完全,住院时间短,费用低。
Objective To investigate the clinical significance of transsphenoidal approach for pituitary adenoma. Methods From September 2000 to September 2008, 63 patients with pituitary adenoma were enrolled. All patients underwent coronal CT reconstruction, dynamic contrast-enhanced MRI and endocrinology examination before operation. All patients underwent single-nostril sphenoid sinus surgery microsurgical tumor resection. Follow-up 3-36 months. Results Totally 51 cases of complete tumor resection, subtotal resection in 8 cases, partial resection in 4 cases. Postoperative symptoms and endocrine examination improved 60 cases, 5 cases of complications, including nasal mucosa infection, transient cerebrospinal fluid rhinorrhea, hypopituitarism. 4 cases of recurrence after 1 year. Conclusion Traumatic transsphenoidal surgery for pituitary adenoma is small, simple, safe, complete tumor resection, short hospital stay and low cost.