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细胞周期是受到严格调控,有大量的细胞分子事件参与才能保证细胞完成DNA复制和细胞分裂[1]。细胞周期调控依赖于细胞周期蛋白(cyclin)、细胞周期蛋白依赖性蛋白激酶(cyclin dependent protein kinase,CDK)和细胞周期依赖性蛋白激酶抑制剂(cyclin dependent protein kinase inhibitors,CDKI)的相互作用,三者之间存在复杂而精密的调控网络,控制着细胞周期的进展,参与细胞的生长、发育、分化、衰老及死亡等病理生理过程[2]。其中CDK属于丝氨酸/苏氨酸蛋白激酶家族,必须与cyclin结合后才能
Cell cycle is strictly regulated, a large number of cellular and molecular events involved in ensuring the completion of DNA replication and cell division [1]. Cell cycle regulation depends on the interaction of cyclin, cyclin dependent protein kinase (CDK) and cyclin dependent protein kinase inhibitors (CDKI) There is a complex and sophisticated regulatory network between the control of the cell cycle progress, involved in cell growth, development, differentiation, aging and death and other pathophysiological processes [2]. Which CDK belongs to serine / threonine protein kinase family, must be combined with cyclin