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目的:我们的研究目的是评价β1肾上腺素受体(beta1-AR)密码子49和389的多态性对于β受体阻滞剂对扩张性心肌病疗效的影响。方法:我们检测了375例扩张性心肌病患者以及492例对照beta1-AR的基因型。结果:密码子49和389的多态性与扩张性心肌病的敏感性均无关联。在对接受β受体阻
PURPOSE: Our aim was to evaluate the effect of β-blockers on the therapeutic efficacy of dilated cardiomyopathy using polymorphisms at codons 49 and 389 of β1-adrenoceptor (beta1-AR). METHODS: We examined genotypes in 375 patients with dilated cardiomyopathy and 492 controls, beta1-AR. RESULTS: There was no association between polymorphisms in codons 49 and 389 and susceptibility to dilated cardiomyopathy. In the right to accept β receptor resistance