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为探讨~(99m)Tc-低密度脂蛋白(LDL)动脉粥样硬化显像的临床应用前景,对9只动脉粥样硬化模型兔和4只对照兔进行~(99m)Tc-LDL 显像,并与放射自显影及组织病理学结果进行了对比分析。结果:高胆固醇高脂肪膳食建立兔动脉粥样硬化模型其成功率为100%;静脉注射~(99m)Tc-LDL24小时,动脉粥样硬化斑块显示良好,9只动脉粥样硬化兔中有8只显示出与动脉粥样硬化斑块分布相一致的放射性聚集影,并与放射自显影显示的黑度有很好的一致性;4只对照兔动脉内未出现放射性聚集影。表明~(99m)Tc-LDL 显像对动脉粥样硬化的诊断具有良好的前景。
To investigate the clinical application of ~ (99m) Tc-LDL atherosclerotic imaging, 99m Tc-LDL imaging was performed in 9 atherosclerotic rabbits and 4 control rabbits , And compared with autoradiography and histopathological results. Results: The success rate of rabbit model of atherosclerosis was 100% with high-cholesterol and high-fat diet. Atherosclerotic plaque showed good at 24 hours after intravenous injection of 99m Tc-LDL, and in 9 rabbits with atherosclerosis 8 showed radioactive aggregation consistent with the distribution of atherosclerotic plaques and showed good consistency with that of autoradiograph. No radioactive aggregation occurred in the 4 control rabbits. It shows that ~ (99m) Tc-LDL imaging has a good prospect for the diagnosis of atherosclerosis.