子痫前期胎盘组织中氧化应激、热休克蛋白27和热休克转录因子1的表达及意义

• 作 者: 张晗 刘方琮 蔡丽瑛
• 机 构: 哈尔滨医科大学第一附属医院妇产科,
• 出 处: 中国计划生育和妇产科
• 发表日期: 2017年08期
• 关键词: 子痫前期 氧化应激 热休克蛋白27 热休克转录因子1

子痫前期(preeclampsia,PE)是妊娠期特有的一种以多脏器功能损害为主的疾病,以妊娠20周后高血压、水肿、蛋白尿为主要临床特征。关于PE的病因及发病机制至今仍未明确,目前大多数学者认为氧化应激与PE发病的关系密切。最新研究表明在氧化应激水平状态下,PE患者胎盘组织中热休克蛋白27及其热休克转录因子1的表达均有不同程度的升高,从而导致滋养细胞过度凋亡是PE发病的关键环节。

Preeclampsia (PE) is a disease characterized by multiple organ dysfunction during pregnancy. Hypertension, edema and proteinuria are the main clinical features after 20 weeks gestation. On the etiology and pathogenesis of PE is still not clear, most scholars believe that oxidative stress and the pathogenesis of PE is closely related. Recent studies have shown that in the oxidative stress state, the expression of HSP27 and its heat shock transcription factor 1 in placental tissue of PE patients all increased to some extent, leading to excessive apoptosis of trophoblast cells is the key link in the pathogenesis of PE .