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目的探讨联合降压治疗2型糖尿病伴高血压的临床疗效。方法研究对象为2007年9月～2010年12月某院收治的2型糖尿病伴高血压患者76例,其中硝苯地平治疗组设为对照组(27例),依那普利和络活喜联合治疗组设为观察组(49例),比较分析两组患者临床疗效及并发症情况。结果观察组总有效率为87.7%;对照组总有效率为51.8%,两组差异有统计学意义(P﹤0.05);治疗前观察组合并糖尿病肾病9例、冠心病11例;对照组合并糖尿病肾病5例、冠心病7例。治疗后观察组糖尿病肾病好转率66.7%,冠心病好转率27.7%;对照组糖尿病肾病好转率25.0%,冠心病好转率28.6%,两组差异有统计学意义(P﹤0.05)。结论在2型糖尿病伴高血压的治疗中联合降压治疗效果显著,安全可靠,值得临床上推广应用。
Objective To investigate the clinical efficacy of combined antihypertensive treatment of type 2 diabetes with hypertension. Methods Totally 76 patients with type 2 diabetes mellitus and hypertension were treated in our hospital from September 2007 to December 2010, including nifedipine treatment group (n = 27), enalapril The treatment group was set as the observation group (49 cases). The clinical efficacy and complications of the two groups were compared. Results The total effective rate in the observation group was 87.7%; the total effective rate in the control group was 51.8%, the difference between the two groups was statistically significant (P <0.05); before treatment, 9 patients with diabetic nephropathy and 11 patients with coronary heart disease were observed; 5 cases of diabetic nephropathy, coronary heart disease in 7 cases. After treatment, the improvement rate of diabetic nephropathy in the observation group was 66.7%, and the improvement rate of coronary heart disease was 27.7%. In the control group, the improvement rate of diabetic nephropathy was 25.0% and the improvement rate of coronary heart disease was 28.6%. There was significant difference between the two groups (P <0.05). Conclusions The combination of antihypertensive therapy in type 2 diabetes mellitus with hypertension has significant effect and is safe and reliable, which is worth popularizing and applying clinically.