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目的研究何首乌不同提取物对小鼠脾脏淋巴细胞的增殖作用。方法Con A诱导T细胞增殖;用XTT法测定淋巴细胞的增殖能力。结果正丁醇和乙酸乙酯萃取物均能直接促进小鼠脾脏淋巴细胞增殖,并能增加Con A诱导的T淋巴细胞增殖,氯仿萃取物能抑制小鼠脾脏淋巴细胞增殖及Con A诱导的T淋巴细胞增殖。结论何首乌的不同活性部位具有不同的免疫调节活性,提示何首乌可能具有双向的免疫调节作用。
Objective To study the effect of different extracts of Polygonum multiflorum on the proliferation of mouse splenic lymphocytes. Methods The proliferation of T cells was induced by Con A and the proliferation of lymphocytes was measured by XTT. Results Both n-butanol and ethyl acetate extracts could directly promote the proliferation of mouse spleen lymphocytes and increase Con A-induced proliferation of T lymphocytes. Chloroform extracts could inhibit the proliferation of mouse splenic lymphocytes and Con A-induced T lymphocytes. Cell Proliferation. Conclusion The different active sites of Polygonum multiflorum have different immunomodulatory activities, suggesting that Polygonum multiflorum may have a bidirectional immunomodulatory effect.