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本文进一步了解吡噻硫酮与对药物生物利用度有影响的饮食之间的关系,以确定治疗所需的准确剂量及测定药物的疗效与患者血药浓度间的相互关系。对Khartoum省附近地区的学生和农民经全面体检后选择肠期、肝肠期或肝脾期的曼氏血吸虫病患者作为研究对象。患者在治疗前每人送检2～3份粪样品,对每克粪便作虫卵计数。44例苏丹男性患者,平均年龄17岁(7～30岁),随机分为3组,每组12人。A组1次口服吡噻硫酮30mg/kg,同时服用定量的棉籽油面包、蚕豆和1杯水。B组和C
This article further explores the relationship between oltipraz and dietary influences on drug bioavailability to determine the exact dose required for treatment and to determine the correlation between the efficacy of the drug and the patient’s plasma concentration. Students and peasants in the area around Khartoum province were selected for the study of patients with Schistosoma mansoni at the stages of intestine, liver, intestine or liver and spleen after a comprehensive physical examination. Patients were tested before delivery 2 ~ 3 copies of fecal samples per gram of stool eggs for the count. Forty-four Sudanese males, mean age 17 years (range, 7 to 30 years), were randomly assigned to 3 groups of 12 in each group. A group of oral oltipraz 30mg / kg, while taking quantitative cottonseed oil bread, beans and a cup of water. Group B and C.