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报告２８例颅脑内生殖细胞瘤，１２例肿瘤位于松果体区，１３例位于鞍区，３例位于丘脑。男性１９例，女性９例，平均年龄１８岁。临床表现：肿瘤位于松果体区者常有颅内压增高，位于鞍区者主要表现为尿崩症，视力受损等。组织学上与睾丸的精原细胞瘤相似，其中５例瘤组织内有ＨＣＧ阳性的合体滋养层巨细胞，１２例伴有肉芽肿。随访２２例，１７例手术切除或活检加放疗者，３例复发死亡，其中２例为生殖细胞瘤伴合体滋养层巨细胞；５例仅手术切除及未放疗者均死亡。结果表明：颅脑内生殖细胞瘤是否伴有合体滋养层巨细胞及肿瘤侵犯扩散范围是影响病人预后的主要因素。
Reported 28 cases of intracranial germinomas, 12 cases of tumors located in the pineal region, 13 cases in the saddle area and 3 cases in the thalamus. 19 males and 9 females, with an average age of 18 years. Clinical manifestations: The tumor is located in the pineal area often increased intracranial pressure, located in the saddle area were mainly for diabetes insipidus, visual impairment and so on. Histologically similar to the testicular seminoma, including 5 cases of HCG-positive syncytiotrophoblastic giant cells, 12 cases associated with granulomas. Twenty-two patients were followed up, 17 patients underwent surgical resection or biopsy plus radiotherapy and 3 patients died of recurrence. Two of them were germ cell tumor with syncytiotrophoblastic giant cells. Only 5 patients underwent resection and no radiotherapy. The results showed that: intracranial germ cell tumor is accompanied by syncytiotrophoblastic giant cells and the scope of tumor invasion is the main factor affecting the prognosis of patients.