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疟原虫对氯喹等抗疟药物的抗性是疟疾治疗的一大难题。举世医药界除了不断寻找疟原虫尚未产生抗性的新药(如青蒿素)以外,也在探索抗性的机埋。前几年揭晓癌细胞对药物抗性原理(见本刊1987,(1):55)启发下,研究者发现氯喹在抗性虫株的蓄积量比在敏感虫株的蓄积量更少,其原因可能由于抗性寄生虫能将药物迅速排出虫体,从而不受药物作用。钙通道阻滞剂维拉帕米(异搏定)抑制寄
Plasmodium resistance to chloroquine and other anti-malarial drugs is a major challenge malaria treatment. In addition to constantly searching for new drugs (such as artemisinin) that Plasmodium have not yet developed resistance, the world pharmaceutical industry is also exploring the possibility of resistance. Inspired by the principle of drug resistance (see Journal 1987, (1): 55) that cancer cells were revealed several years ago, the researchers found that chloroquine accumulated less in resistant strains than in sensitive strains The reason may be due to resistant parasites can quickly expel the drug out of the body, so that the role of the drug. Calcium channel blocker verapamil (verapamil) inhibit send