大蒜和大蒜绿茶合剂防治实验性胃癌及癌前病变中血脂的变化

• 作 者: 苏琦 罗招阳 腾华 尹卫东 李一琴 贺兴娥
• 机 构: 衡阳医学院肿瘤研究所
• 出 处: 华人消化杂志
• 发表日期: 1998年02期
• 关键词: 大蒜 绿茶 合剂 防治 实验性 胃癌 癌前病变 血脂

目的在甲基硝基亚硝基胍（ＭＮＮＧ）诱发大鼠胃腺癌及癌前病变的过程中，观察血Ｔｃｈ，ＬＤＬ，ＨＤＬ的变化及大蒜和大蒜绿茶合剂的影响．方法采用血清ＨＤＬ和ＬＤＬ聚乙二醇沉淀分离同步测定法，检测正常对照组（ＮＧ）１０只，ＭＮＮＧ（ＭＧ）３０只，预防组（ＰＧ）３０只，治疗Ⅰ组（ＴＧⅠ）２０只和治疗Ⅱ组（ＴＧⅡ）２０只血Ｔｃｈ，ＬＤＬ，ＨＤＬ（ｘ±ｓ）（ｇ／Ｌ）．结果各组Ｔｃｈ，ＬＤＬ，ＭＧ（６８６±１３９，３７２±１１０）及其胃癌（６９５±１３７，３７７±１０８）与癌前病变（６４２±１０４，３５６±０７４）皆分别低于ＮＧ（８７４±１８９，５８９±１６１）、ＰＧ（７７３±３１８，４９６±２８９）及其胃癌（８３６±３４１，５９３±３３１）与癌前病变（７４５±３１６，４５５±２７１）、ＴＧⅠ（８８６±１７５，５３８±１７６）及其胃癌（９１０±２２７，５５５±２５１）与癌前病变（８６１±１１７，５２２±０５５）、ＴＧⅡ（８１６±０７６，５３２±０７２）及其胃癌（８５２±０６７，５９６±０４８）与癌前病变（８０２±０７９，５?

Objective To observe the changes of Tch, LDL and HDL in blood and the effect of garlic and garlic green tea mixture in the process of rat gastric adenocarcinoma and precancerous lesion induced by MNNG. Methods Simultaneous determination of serum HDL and LDL polyethylene glycol was used to isolate and measure synchronously. 10 normal control groups (NG), 30 MNNG (MG), 30 prevention group (PG) and 20 treatment group I (TGI) were detected. T2, LDL, and HDL (x±s) (g/L) were measured in 20 patients in Group II (TGII). Results Tch, LDL, MG (686±139,372±110) and gastric cancer (695±137,377±108) and precancerous lesions were observed in each group ( 642±104, 356±074) are all lower than NG (874±189, 589±161), PG (773±318, 4) 96±289) and its gastric cancer (836±341,593±331) and precancerous lesions (745±316,455±271), TGI (886±175, 538±176) and its gastric cancer (910±227, 555±251) and precancerous lesions (861±117, 522±055), TGII(816±076,532±072) and gastric cancer (852±067, 596±048) and precancerous Lesions (802±079, 5?