PHARMACOLOGICAL STUDY OF AN IRREVERSIBLE PARTIAL AGONIST OF OPIATE RECEPTORS, A-α-CAO

• 作 者: 李明霞 李灵源 李北波 金荫昌 仇缀百 朱淬砺
• 机 构: InstituteoFBasicMedicalSciences,ChineseAcademyofMedicalSciences,Beijing,FacultyofPharmacy,ShanghaiMe
• 出 处: Science in China,Ser.B
• 发表日期: 1989年3期
• 关键词: analgesia agonist naloxone affinity morphine removed opioid analgesic allyl anta

A-α-CAO induces weak analgesia with very short duration in mice and is able to antagonize the analgesic effect of morphine （Mor） up to 3—4 days after a single injection. No tendency of dependence has been observed. It acts as a partial agonist on MVD with