论文部分内容阅读
尽管已作了15年的深入研究,但并没有证明EB病毒是非洲人Burkitt氏淋巴瘤和鼻咽癌(NPC)的病因。研究Burkitt氏淋巴瘤的意外收获是证实了EB病毒能引起传染性单核细胞增多症。本文评论了证实传染性单核细胞增多症是恶性淋巴瘤的良性副本的证据;略述为什么免疫缺陷和细胞遗传性改变能使多细胞系的传染性单核细胞增多症转化为单细胞系的恶性淋巴瘤;并简述了持续的抗原刺激、伴随着免疫缺陷,是个体经EB病毒诱发肿瘤的先决条件,以及为什么EB病毒感染后恶性淋巴瘤能得以发展。
Despite 15 years of intensive research, the EB virus has not been proven to be the cause of Burkitt’s lymphoma and nasopharyngeal carcinoma (NPC) in Africa. The unexpected discovery of Burkitt’s lymphoma is evidence that Epstein-Barr virus can cause infectious mononucleosis. This article reviews the evidence that infectious mononucleosis is a benign copy of malignant lymphoma; outlines why immunodeficiency and cytogenetic changes can translate multicellular infectious mononucleosis into single cell lines Malignant lymphomas; and a brief description of persistent antigenic stimuli, along with immunodeficiency, is a prerequisite for an individual to develop an EBV-induced tumor and why EBV-infected malignant lymphomas can develop.