Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expressi

• 作 者: Xiao-qun HAN San-qing XU Jian-
• 机 构: DepartmentofMicrobiologyandImmunology,DepartmentofPediatrics,P3BiosafetyLaboratory,AffiliatedNanyueH
• 出 处: 当代医学科学(英文)
• 发表日期: 2019年5期
• 关键词: hepatic stellate cells LIPID droplets perilipins CURCUMIN liver FIBROSIS
• 基金项目: This study was supported by the National Natural Science Foundation of China(No.81760356)to Dr.Xiao-qun HAN and Talent Initial Funding(No.YY2017-002)sponsored by Guangdong Second Provincial General Ho

The activation of hepatic stellate cells(HSCs)is a major event during hepatic fibrogenesis.Restoration of intracellular lipid droplet(LD)formation turns the activated HSC back to a quiescent state.Our previous studies have shown that curcumin suppresses H