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A群链球菌可以引起多种疾病,从咽炎和脓皮病到危及生命的感染,在某些个体中可由咽炎引发急性风湿热,目前急需预防A群链球菌病的菌苗。表面M蛋白是A群链球菌的主要保护性抗原,抗M蛋白抗体具有调理作用并能促进吞噬细胞杀灭病原体。先前的4价及8价M蛋白菌苗研究表明,菌苗的免疫原性与羧基末端片段是否转换到内部位置有关,根据这一信息作者构建了6价M蛋白菌苗,为了“保护”羧基末端组分,作者将
A group of Streptococcus can cause a variety of diseases, from pharyngitis and pyoderma to life-threatening infections, in some individuals can be caused by pharyngitis acute rheumatic fever, the urgent need to prevent group A streptococcal vaccine. Surface M protein is the main protective antigen of Group A Streptococcus, anti-M protein antibodies have a role in conditioning and can promote phagocytosis of pathogens. Previous studies of the 4-valent and 8-valent M-protein bacterins showed that the immunogenicity of the bacterin was related to whether the carboxyl terminal fragment was translocated to the internal site. Based on this information, the authors constructed a 6-valent M protein bacterin in order to “protect” End components, the author will