论文部分内容阅读
作者对9-去氧-16,16-二甲基-9-甲撑-PGE(Ⅰ)的生物学活性进行了实验,并与16,16-二甲基-PGE_2(Ⅱ)作了比较。兴奋子宫及堕胎药活性是用怀孕(110～144天)恒河猴为实验动物,用盐酸Phencyclidine麻醉后将充满液体的聚乙烯管经腹插入羊膜腔,通过Statham P-23Dc转换器和多笔记录仪测定子宫压力。药物溶于无水乙醇用pH7.6,0.1M磷酸缓冲液稀释,其浓度调到注射量为0.1～0.5ml,静注(大隐静脉)或肌注。阴道给时可将水溶液置于可见的宫颈部位。或将药物制成栓剂放在阴道穹窿高
The authors tested the biological activity of 9-deoxy-16,16-dimethyl-9-methylene-PGE (I) and compared it to 16,16-dimethyl-PGE 2 (II) Exciting uterus and abortion drug activity is pregnant (110 ~ 144 days) rhesus monkeys as experimental animals, anesthesia with hydrochloric acid Phencyclidine will be filled with liquid polyethylene tube into the amniotic membrane by abdominal, through the Statham P-23Dc converter and multiple Recorder determines uterine pressure. Drugs dissolved in anhydrous ethanol diluted with phosphate buffer pH7.6,0.1 M, the concentration transferred to the injection volume of 0.1 ~ 0.5ml, intravenous (saphenous vein) or intramuscular injection. When the vagina can be placed in the visible aqueous solution of the cervix. Or suppository drugs placed in the vaginal vault high