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目的:探索药源性胚泡异常与着床后胚胎毒性和发育缺陷间的关系。方法:大鼠在孕d3 ig阿司匹林(0.25,0.5,和1g·kg~(-1))。孕d 4将胚泡移植于假孕大鼠(与连续5dig氯丙二醇5mg·kg~(-1)大鼠交配获得)子宫内。临产前检查子宫内胚胎。结果:孕d4给药组胚泡异常率增高,着床率低于对照组,试验组的胚胎吸收率(55.2％,69.5％,和85.2％)与畸胎率(3.8％,44.4％,和25％)呈剂量依赖性增高,活胎率降低(44.8％,30.5％,和14.8％),并与胚泡异常率呈相关性。结论:大鼠在胚泡植入前给阿司匹林可导致呈剂量依赖关系的胚胎毒性和畸胎。
Objective: To explore the relationship between drug-induced blastocyst anomalies and embryo toxicity and developmental defects after implantation. METHODS: Rats were dosed with ig aspirin (0.25, 0.5, and 1 g · kg -1) during pregnancy. Pregnant d 4 The blastocysts were transplanted in the pseudopregnant rat (with 5dig 5mg · kg -1 continuous rat copulation access) intrauterine. Prenatal examination of intrauterine embryos. Results: The abnormal rate of blastocyst in pregnancy d4 administration group was higher than that in control group. The embryo absorptivity (55.2%, 69.5%, 85.2%) and teratogenic rate (3.8%, 44.4% 25%) showed a dose-dependent increase in live birth rate decreased (44.8%, 30.5%, and 14.8%), and the blastocyst anomalies were correlated. CONCLUSIONS: Aspirin administration in rats prior to blastocyst implantation resulted in embryotoxicity and teratogenicity in a dose-dependent manner.