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Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer.This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field(AMF) and investigated whether this method offers a therapeutic option for esophageal cancer.Nitinol stents were placed in the cervical esophagi of healthy rabbits,which were heated in an AMF for different times at 43,46 and 50℃.The esophagi were histologically examined after a week to observe whether there was transmural necroses.Then esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46℃for 10 min.Stents were heated to a target temperature within 5 min.The highest tolerated temperature and time for the healthy rabbit esophagus was at 46℃for 10 min.Tumor growth was delayed by heating and it was statistically significant.Heating the rabbit esophageal wall at 46℃for 10 min proves to be safe and effective in delaying tumor growth.
Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer. This study estimates the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field (AMF) and check whether this method offers a therapeutic option for esophageal cancer .Nitinol stents were placed in the cervical esophagi of healthy rabbits, which were heated in an AMF for different times at 43,46 and 50 ° C. The esophagi were histologically examined after a week to observe whether there was transmural necroses. rabbit placed nitinol stents were heated in an AMF at 46 ° C for 10 min. Tents were heated to a target temperature within 5 min. The highest tolerated temperature and time for the healthy rabbit esophagus was at 46 ° C for 10 min. Tumor growth was delayed by heating and it was significant significant. Heating the rabbit esophageal wall at 46 ° C for 10 min proves to be safe and effective in delaying tumor growth.