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减毒麻疹活疫苗的应用大大地减少了麻疹及其并发症的发生率。但在1961～1964时早期临床试用阶段所应用的吸附于明矾上的甲醛灭活Edmonston株病毒作预防接种却是失败的。对儿童曾先给予2次死病毒注射,然后再予1次活的Edmonston株病毒疫苗(KKL)注射或是注射3次死病毒疫苗(KKK)。这些儿童不仅感染上麻疹,而且其中有些儿童发生非典型麻疹,表现为伴有头痛、畏光及咳嗽的热性疾病。皮疹不是从面颈部开始,而是从手足开始发出斑疹、丘疹,有时为小水疱。未见Koplik氏斑,绝大多数病例有广泛的且往往为单侧性的肺部侵润。本病的发病机理一直
The use of live attenuated measles vaccine has greatly reduced the incidence of measles and its complications. However, inactivation of the Edmonston strain of formaldehyde adsorbed to alum on early clinical trials from 1961 to 1964 was unsuccessful. The children were given two deaths of the virus first, followed by one live Edmonston strain of vaccine (KKL) or three deaths of the vaccine (KKK). Not only were these children infected with measles, but some of them had atypical measles, a febrile illness with headaches, photophobia and coughing. Rash is not from the face and neck began, but from the hands and feet began to send rash, papules, and sometimes small blisters. No Koplik’s stain was found, and the vast majority of cases were extensive and often unilateral lung invasion. The pathogenesis of this disease has been