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目的采用低压缺氧法建立高原气虚血瘀证大鼠模型。方法将实验大鼠减压至相当于海拔6 000m的高度,每天3.5h,共计6周,观察大鼠表征、摄食量、体质量、耐疲劳时间和血液流变学等指标的变化。结果与对照组比较,模型大鼠皮毛黯淡枯燥、蓬松、脱毛,耳朵、尾巴、爪甲色泽黯红,或有瘀斑,舌质紫黯,倦怠嗜睡,精神委顿,四肢蜷缩,活动性差,攻击性、对抗性减少或消失,摄食量减少,体质量降低,抗疲劳能力降低,血浆黏度和全血黏度升高(P<0.05)。结论以低压缺氧法建立的气虚血瘀证大鼠疾病模型,其表征和血液流变学指标符合气虚血瘀证的表现。
Objective To establish a rat model of Qi deficiency and blood stasis in the plateau by hypobaric hypoxia. Methods The rats were decompressed to a height of 6 000 m above sea level for 3.5 hours a day for a total of 6 weeks. The changes of rat indicators such as food intake, body weight, fatigue time and hemorrheology were observed. Results Compared with the control group, the fur of the model rats was dull, fluffy and hairless. The ears, tail and claws had dark red color or ecchymosis, dark purple tongue, tiredness and drowsiness, mental retardation, curled limbs, poor mobility and attack Sex, antagonism decreased or disappeared, food intake decreased, body mass decreased, anti-fatigue ability decreased, plasma viscosity and whole blood viscosity increased (P <0.05). Conclusion The model of Qi deficiency and blood stasis in rats established by hypobaric hypoxia method is characterized by its characterization and hemorrheological indexes in line with the performance of Qi-deficiency and blood-stasis syndrome.