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目的:对高敏C-反应蛋白(hs-CRP)与急性冠脉综合征(ACS)及其预后的关系进行相关探讨,为ACS的防治以及高敏C-反应蛋白在ACS患者预后中所起到的作用提供科学依据。方法:选择2008-01/2010-05入住我院符合ACS诊断标准的患者作为病例组,其中包括不稳定型心绞痛(UAP)患者42例,急性心肌梗死(AMI)患者38例;选取同期在我院门诊上健康体检的健康人44例和入住我院的稳定型心绞痛(SAP)患者40例作为对照组。对所有研究对象的血清采用双抗体夹心酶联免疫吸附法(ELASA法)进行hs-CRP表达水平的检测。结果:4组研究对象hs-CRP平均浓度比较,差异具有统计学意义(P<0.05),其中病例组(包括AMI患者和UAP患者)的hs-CRP表达水平均高于SAP组,SAP患者血清中的hs-CRP高于健康体检者。组间两两比较差异均具有统计学意义(P<0.01)。多因素Logistic回归分析发现hs-CRP为ACS的危险因素,并且其表达水平与ACS成正相关(P<0.05)。结论:ACS患者的hs-CRP表达水平与对照组相比显著增高,与ACS患者的病情轻重也有关,hs-CRP对ACS患者的预后具有一定预测价值。
OBJECTIVE: To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) and acute coronary syndrome (ACS) and its prognosis, to prevent and treat ACS and the prognosis of high-sensitivity C-reactive protein Provide a scientific basis for the role. Methods: A total of 42 patients with unstable angina pectoris (UAP) and 38 patients with acute myocardial infarction (AMI) admitted to our hospital from January 2008 to May 2010 were selected as the case group. Forty-four healthy subjects in outpatient clinics and 40 patients with stable angina pectoris (SAP) admitted to our hospital served as control group. All subjects were tested for hs-CRP expression using double antibody sandwich enzyme-linked immunosorbent assay (ELASA). Results: The average concentration of hs-CRP in the four groups of patients was significantly different (P <0.05). The hs-CRP expression levels in case group (including AMI patients and UAP patients) were higher than those in SAP group The hs-CRP was higher in healthy subjects. The differences between groups were statistically significant (P <0.01). Multivariate Logistic regression analysis found that hs-CRP was a risk factor for ACS, and its expression level was positively correlated with ACS (P <0.05). Conclusions: The hs-CRP expression in patients with ACS is significantly higher than that in the control group, which is also related to the severity of ACS. Hs-CRP has some predictive value in the prognosis of patients with ACS.