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目的:探讨急性冠脉综合征(ACS)早期应用辛伐他汀对血脂、缺血事件发生情况的影响。方法:将50例ACS患者随机分为对照组(n=25)和治疗组(n=25),观察用药前后血脂、缺血事件发生情况。结果:对照组治疗前后血脂无显著变化(P>0.05),治疗组用药后血脂明显下降(P<0.05)。与对照组相比,治疗组缺血事件发生率明显下降(2χ=4.68,P<0.05)。两组治疗前后肝、肾功能,肌酸磷酸激酶均无变化。结论:ACS早期应用辛伐他汀可明显降低缺血事件发生。
Objective: To investigate the effect of early application of simvastatin on the incidence of blood lipids and ischemic events in patients with acute coronary syndrome (ACS). Methods: Fifty ACS patients were randomly divided into control group (n = 25) and treatment group (n = 25). The incidence of blood lipid and ischemic events before and after treatment were observed. Results: There was no significant change in blood lipid in the control group before and after treatment (P> 0.05). The blood lipids in the treatment group decreased significantly (P <0.05). Compared with the control group, the incidence of ischemic events in the treatment group decreased significantly (2χ = 4.68, P <0.05). Liver and kidney function and creatine phosphokinase did not change in both groups before and after treatment. Conclusion: Early application of simvastatin can significantly reduce the incidence of ischemic events.