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目的 :研究晚期胰腺癌患者凝血、抗凝、纤溶功能的变化 ,并探讨其临床意义。方法 :以 PT、APTT、Fg、VWF等四项指标检测凝血功能 ,以 AT- A、AT- Ag、PC∶ A反映抗凝功能 ,PL g、tp A∶ A、PAI∶ A、FDP等四项指标反映纤溶功能 ,并与正常人群对照。结果 :在晚期胰腺癌组 ,PT、APTT明显延长 (P<0 .0 1) ,Fg、VWF升高 (P<0 .0 1) ,AT- A%降低 (P<0 .0 1) ,AT- Ag、PC∶ A升高 (P<0 .0 1) ,而 PL g、tp A∶ A、PAI∶ A均降低 (P<0 .0 1) ,FDP明显升高 (P<0 .0 0 1)。结论 :晚期胰腺癌患者存在明显的凝血、抗凝、纤溶异常 ,原因与胰腺癌本身有关 ,如不加以正确处理 ,将使病情恶化。
Objective: To study the changes of coagulation, anticoagulation and fibrinolysis in patients with advanced pancreatic cancer and to explore its clinical significance. Methods: Coagulation function was detected with PT, APTT, Fg, VWF, etc. The anticoagulation function was reflected by AT-A, AT-Ag, PC: A, PL g, tp A: A, PAI: A, FDP, etc. The index reflects the fibrinolytic function and is compared with the normal population. Results: In the advanced pancreatic cancer group, PT and APTT were significantly prolonged (P < 0.01), Fg and VWF were elevated (P <0.01), and AT-A% was decreased (P <0.01). AT-Ag and PC:A increased (P<0. 01), while PL g, tp A: A, and PAI: A decreased (P < 0.01), and FDP increased significantly (P <0. 0 0 1). Conclusion: There are obvious coagulation, anticoagulation and fibrinolysis in patients with advanced pancreatic cancer. The causes are related to pancreatic cancer itself. If not treated correctly, it will make the disease worse.