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肝纤维化是慢性肝疾病的病理基础,是肝脏对慢性损伤的修复作用,大量的细胞外基质蛋白异常沉淀最终导致肝硬化的形成.现认为肝纤维化尚有逆转至正常的可能.肝纤维化的发病机制很复杂,更有效的低毒的治疗药物也有待发现.近年来各种体内体外实验均发现NOX和ERK在发生纤维化中起关键作用.本文就NOX和ERK与肝纤维化的关系进行了综述.“,”Hepatic fibrosis is the pathological consequence of chronic liver disease.As a result of the repair of chronic liver injury,extracellular matrix protein accumulates and ultimately leads to cirrhosis.Current research has indicated that liver fibrosis might be reversed.The pathogenesis of hepatic fibrosis is very complex,and more effective treatments with a low toxicity must be identified.In recent years,various data from in vivo and in vitro experiments have indicated that NOX and ERK play a key role in the development of fibrosis.This review discusses the relationship between NOX and ERK and liver fibrosis.