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目的 :探讨蛛网膜下腔出血 (SAH)急性期血浆脑钠素 (BNP)含量与低钠血症的关系。方法 :用放射免疫检测法测定 36例SAH急性期患者病程 0～ 2d(Ⅰ期 )、7～ 9d(Ⅱ期 )和 >14d(Ⅲ期 )血浆BNP含量。Ⅱ期还测定抗利尿素 (ADH)、心钠素 (ANP)和去甲肾上腺素 (NA)血浆浓度。结果 :2 2例低钠血症 (血钠浓度 <135mEq/L)各期血浆BNP浓度与对照组有显著差异。低钠血症者Ⅱ期血浆BNP浓度显著高于Ⅰ期、Ⅲ期 (P <0 0 5 )。Ⅱ期患者中 ,伴低钠血症者血浆NA浓度高于血钠正常者 (P <0 0 5 ) ,而两者血浆ADH、ANP浓度无显著差异。结论 :血浆BNP与低血钠间可能有一定关系 ;NA可能与BNP分泌有关。
Objective: To investigate the relationship between plasma brain natriuretic peptide (BNP) and hyponatremia in patients with acute subarachnoid hemorrhage (SAH). Methods: Plasma BNP levels in 36 SAH patients during the course of 0 ~ 2d (stage Ⅰ), 7 ~ 9d (stage Ⅱ) and> 14d (stage Ⅲ) were determined by radioimmunoassay. Phase II was also tested for plasma concentrations of anti-diuretic (ADH), atrial natriuretic peptide (ANP) and norepinephrine (NA). Results: There were significant differences in plasma BNP concentrations in 22 cases of hyponatremia (serum sodium concentration <135mEq / L) and control group. Plasma BNP levels in patients with hyponatremia were significantly higher than those in patients in stage I and III (P <0.05). Among the patients with stage Ⅱ, the plasma NA concentration in patients with hyponatremia was higher than those with normal serum sodium (P <0.05), while there was no significant difference in plasma ADH and ANP concentrations between the two groups. Conclusion: There may be a relationship between plasma BNP and hyponatremia; NA may be related to the secretion of BNP.