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已有研究表明,移行细胞癌有c-erB-2基因的扩增和过度表达,但迄今为止,有关c-erB-2的细胞定位尚有争论,为此作者对移行细胞癌进行了South-ern、Northern、免疫印迹,免疫细胞化学的综合分析,以确定c-erB-2的表达情况及细胞定位。 作者选用不同级别移行细胞癌(82例),活检原位癌(4例)及原位癌患者尿细胞(5例)为实验组。对照选用病人外周血(25例),膀胱癌病人的“正常”膀胱上皮组织(39例)无肿瘤病人的膀胱上皮组织(10例),膀胱内病变组织(22例),志愿者外
Studies have shown that there are c-erB-2 gene amplification and overexpression in transitional cell carcinoma, but so far there is still controversy about the cell localization of c-erB-2. To this end, ern, Northern, Western blot, immunocytochemistry to determine c-erB-2 expression and cellular localization. The authors selected different grades of transitional cell carcinoma (n = 82), biopsy in situ carcinoma (n = 4) and urinary cells (n = 5) as the experimental group. The control group included 25 cases of peripheral blood of patients, 10 cases of normal bladder epithelial tissue (39 cases) without bladder cancer, 22 cases of bladder diseased tissue (22 cases), non-volunteers