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目的:研究氢氧化钠溶液瘤内注射对肝癌的生长抑制作用并探索其机制。方法:对SMMU-LTNM肝癌裸鼠皮下模型进行2%浓度的氢氧化钠溶液瘤内注射,检测肿瘤组织微血管密度、HIF-1α和VEGF的表达情况。结果:与生理盐水瘤内注射组相比,氢氧化钠显著抑制肿瘤生长(P<0.01)、降低肿瘤微血管密度(P=0.01)、抑制肿瘤组织HIF-1α和VEGF的表达(P=0.02和P=0.01)。结论:氢氧化钠瘤内注射可有效抑制肝癌生长,主要机制可能是抗血管生成作用。
Objective: To study the inhibitory effect of intratumoral injection of sodium hydroxide solution on the growth of liver cancer and explore its mechanism. Methods: SMMU-LTNM hepatocellular carcinoma subcutaneous model was injected intratumorally with 2% sodium hydroxide solution to detect the expression of microvessel density, HIF-1α and VEGF in tumor tissue. Results: Sodium hydroxide significantly inhibited tumor growth (P <0.01), reduced microvessel density (P = 0.01), and inhibited the expression of HIF-1α and VEGF in tumor tissues P = 0.01). Conclusion: Intratumoral injection of sodium hydroxide can effectively inhibit the growth of liver cancer, the main mechanism may be anti-angiogenic effect.