论文部分内容阅读
目的:探讨运动对自发性高血压大鼠(SHR)血小板NO及自由基代谢的影响。方法:10周龄雄性SHR随机分为2组:对照组和运动组。运动组大鼠进行为期10周、每周5次、每次60分钟的游泳运动训练。实验后测定两组大鼠血小板最大聚集率、血小板内NO含量、一氧化氮合酶(NOS)活性、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量。结果:运动组大鼠血小板最大聚集率和血小板MDA含量较对照组显著降低,血小板NO含量、NOS活性及SOD活性较对照组显著增高。结论:有氧运动能提高血小板NO含量和生物活性,降低血小板聚集性,这可能与有氧运动提高血小板NOS活性和降低血小板内脂质过氧化水平有关。
Objective: To investigate the effect of exercise on NO and free radical metabolism in platelet of spontaneously hypertensive rats (SHR). Methods: 10-week-old male SHR were randomly divided into two groups: control group and exercise group. Exercise rats for 10 weeks, 5 times a week, each 60 minutes of swimming training. After the experiment, the maximum platelet aggregation rate, the content of NO in platelets, the activity of nitric oxide synthase (NOS), the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in the two groups were measured. Results: The maximum platelet aggregation rate and platelet MDA content in exercise group were significantly lower than those in control group. The NO content, NOS activity and SOD activity in platelet of rats in exercise group were significantly higher than those in control group. Conclusion: Aerobic exercise can increase platelet NO content and bioactivity and reduce platelet aggregation, which may be related to aerobic exercise to increase platelet NOS activity and reduce platelet lipid peroxidation levels.