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美国阿肯色州痰涂片阳性肺结核患者服异烟肼(INH)和利福平(RFP)治疗9个月95%获得成功.本文探讨对痰涂片阴性(至少3次)、培养阳性的肺结核患者能否将疗程缩短至6个月。符合标准者286例,平均年龄68.2(18～99)岁。伴有糖尿病、酒精中毒等“危险因素”者68例(23.7%)。全部接受INH300mg 和RFP600mg qd1个月,继之以INH900mg 和RFP600mg 2次/w,进行5个月治疗。未完成化疗者75例(26.2%),其中因药物副作用而需改变化疗方案者33例,但严重副作用者仅8
Ninety-five percent of patients with sputum smear-positive pulmonary tuberculosis (INH) and rifampicin (RFP) were successfully treated in the United States in the United States of America.This study aimed to determine whether tuberculosis patients who were negative for sputum smear (at least 3 times) Can the treatment be shortened to 6 months. In line with the standard 286 cases, the average age of 68.2 (18 to 99) years old. 68 cases (23.7%) were accompanied by “risk factors” such as diabetes and alcoholism. All received INH300mg and RFP600mg qd for 1 month, followed by INH900mg and RFP600mg 2 times / w for 5 months. Thirty-five patients (26.2%) did not complete chemotherapy, among which 33 patients needed to change chemotherapy regimens due to drug side effects, but only 8