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胶质瘤是中枢神经系统发病率最高的恶性肿瘤,目前的治疗方法是以手术为主、放化疗为辅的分级分型个体化综合治疗,其中手术为最快速和有效去除肿瘤组织的手段。由于肿瘤常呈浸润性生长,术中肿瘤边界显示不清,要达到术中全切非常困难。提高肿瘤边界判断的准确性,以助于术者最大限度地切除肿瘤,便成为改善患者预后的主要方法。术中实时荧光显像技术为近年来蓬勃发展的判断肿瘤边界的新技术。目前国际上荧光显像方法主要有δ-氨基-γ-酮戊酸、荧光素钠、纳米荧光探针、靛氰绿、多光子激发荧光等引导的荧光显像法,前两者相对较成熟而后三者仍处于研究之中。本文就术中实时荧光显像在胶质瘤术中应用进行阐述。
Glioma is a malignant tumor with the highest incidence of central nervous system. At present, the treatment is based on surgery and radiotherapy and chemotherapy combined with fractional and individualized comprehensive treatment, in which surgery is the most rapid and effective means of removing tumor tissue. Due to the tumor often showed invasive growth, intraoperative tumor margin is not clear, to achieve full removal of intraoperative very difficult. To improve the accuracy of tumor boundary judgments to help the surgeon to maximize the removal of the tumor, has become the main method to improve the prognosis of patients. Intraoperative real-time fluorescence imaging technology for the rapid development in recent years to determine the tumor border of the new technology. At present, fluorescent imaging methods such as δ-amino-γ-keto valeric acid, sodium fluorescein, nanofluorescence probe, indocyanine green and multiphoton excitation fluorescence are the main methods of fluorescence imaging in the world. The former two are relatively mature Then the three are still under study. This article describes the application of intraoperative real-time fluorescence imaging in glioma surgery.