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本文旨在研究Forskolin(简称FOR)对特发性充血型心肌病(ICC)病人的心血管效应,并与多巴酚丁胺(DOB)和硝普钠(NIT)进行比较。方法 12例NYHAⅢ级的男性ICC病人参加了本研究。研究前使伴有药物稳定不变至少5～7天。研究前12小时插入Swan-Ganz导管以备测定有关血流动力学参数。本试验分三次给药,每次给药间隔为1～2小时,具体方法如下:FOR的给药速度依次为每分钟0.5、1.0、2.0和3.0μg/kg,给药时间为15分钟;DOB的给药速度依次为每分钟2.5、5.0、7.5和10.0μg/kg,给药时间为15分钟;NIT初始给药速度为每分钟1.5～
This article aims to investigate the cardiovascular effects of Forskolin (FOR) on patients with idiopathic congestive cardiomyopathy (ICC) and to compare it with dobutamine (DOB) and sodium nitroprusside (NIT). Methods Twelve NYHA class III male ICC patients participated in this study. Before the study with the stability of the drug for at least 5 to 7 days. Swan-Ganz catheter was inserted 12 hours prior to study to determine the relevant hemodynamic parameters. The test is divided into three doses, each administration interval of 1 to 2 hours, the specific method is as follows: FOR administration rates of 0.5, 1.0, 2.0 and 3.0 μg / kg per minute, administration time of 15 minutes; DOB In the order of 2.5, 5.0, 7.5 and 10.0 μg / kg per minute for 15 minutes; the initial administration rate of NIT was 1.5 ~