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体内每个组织实际上都能合成前列腺素类(以下简称PG)。各种刺激均可促使PG类释放,其中包括激素的刺激(如缓激肽、血管紧张素Ⅱ),神经的刺激或外源性神经递质,机械损害和降低氧张力等的刺激。PG的储存目前尚无证据,所以有释放就反映有合成。动脉血中几乎无PG,这主要是由于肺部大量破坏PG之故,因此PG类应着成是在其作用部位或在其作用部位附近合成的局部激素。多聚不饱和脂肪酸甘碳5,8,11,14四烯酸(花生四烯酸)和廿碳8,11,14三烯酸(即2—高—r—亚麻酸)通过酶氧化反应而分别形成PG_2和
Each tissue in the body can actually synthesize prostaglandins (hereinafter referred to as PG). Various stimuli can promote the release of PGs, including hormone stimulation (such as bradykinin, angiotensin II), nerve stimulation or exogenous neurotransmitters, mechanical damage and reduce the oxygen tension and other stimuli. There is no evidence for the storage of PG, so the release reflects the synthesis. There is almost no PG in the arterial blood, which is mainly due to the massive destruction of PG in the lung. Therefore, PGs should be considered to be local hormones synthesized at or near their site of action. The polyunsaturated fatty acids glycine 5,8,11,14tetraenoic acid (arachidonic acid) and decane carbon 8,11,14 trienoic acid (ie, 2-high-r-linolenic acid) are subjected to enzymatic oxidation. Separately form PG_2 and