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目前,70岁以下的急性非淋巴细胞性白血病的成人患者,经强烈的诱导化疗,大多数能获得完全缓解。为了长期保持缓解,曾制订了各种维持化疗的方案,但平均缓解期很少超过1年。本文介绍一种适用门诊的简便的维持化疗方案——每周第1～4天口服6-硫鸟嘌呤(每公斤2毫克),第5天肌注阿糖胞甙(每公斤1.5毫克)。 24例(男15例,女9例),平均年龄44.5岁(范围17～72岁)。1例急性单核细胞性白血病,4例急性早幼粒细胞性白血病,19例急性原髓细胞性白血病。获得缓解是用以下3种化疗方案之一:红比霉素+强的松的4例,阿糖胞甙+6-硫鸟嘌呤的9例,阿
At present, most adult patients with acute non-lymphocytic leukemia under 70 years of age receive maximal remission with intensive induction chemotherapy. In order to maintain long-term relief, have developed a variety of chemotherapy regimens, but the average remission rarely more than 1 year. This article describes a simple, outpatient, regimen of maintenance chemotherapy - 6-thioguanine (2 mg / kg) on days 1 to 4 of weekly oral administration and cytosolic arabinoside (1.5 mg / kg) on day 5. 24 cases (15 males and 9 females) with an average age of 44.5 years (range 17-72 years). 1 case of acute monocytic leukemia, 4 cases of acute promyelocytic leukemia and 19 cases of acute myelogenous leukemia. Get relief is the use of one of the following three chemotherapy regimens: 4 cases of rubenicomycin + prednisone, 9 cases of cytarabine + 6-thioguanine, A