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目的探讨表皮生长因子（ＥＧＦ）与胎儿宫内发育迟缓（ＩＵＧＲ）的关系。方法用放射免疫分析法，测定８６例妊娠晚期妇女血清、羊水和脐静脉血清ＥＧＦ浓度；根据新生儿出生体重，将研究对象分成对照组５４例、大于胎龄儿（ＬＧＡ）组１８例和ＩＵＧＲ组１４例。对照组中有１１例同时测定脐动脉血清ＥＧＦ浓度，比较各组间羊水和孕妇、脐血清ＥＧＦ水平及脐动、静脉血清间ＥＧＦ水平的差异。结果ＬＧＡ组羊水、孕妇和脐静脉血清ＥＧＦ与对照组比较，差异无显著性（Ｐ均＞０．２）；与对照组比较，ＩＵＧＲ组羊水ＥＧＦ浓度显著降低，孕妇、脐静脉血清ＥＧＦ浓度显著增高，差异均有显著性（Ｐ均＜０．０５）；与ＬＧＡ组比较，ＩＵＧＲ组脐静脉血清ＥＧＦ浓度显著增高（Ｐ＜０．０５），羊水和孕妇血清ＥＧＦ浓度比较，差异无显著性（Ｐ均＞０．０５）。脐动、静脉血清ＥＧＦ浓度比较，差异无显著性（Ｐ＞０．１）。结论羊水、孕妇及胎儿血ＥＧＦ可能有不同的来源；ＥＧＦ可能与ＩＵＧＲ的发生有关。
Objective To investigate the relationship between epidermal growth factor (EGF) and intrauterine growth retardation (IUGR). Methods Radioimmunoassay was used to determine the EGF concentration of serum, amniotic fluid and umbilical vein in 86 pregnant women. According to the newborn’s birth weight, the subjects were divided into control group (n = 54), 18 cases larger than gestational age (LGA) group and IUGR Group of 14 cases. The control group, 11 cases of simultaneous determination of umbilical artery serum EGF concentration, amniotic fluid between pregnant women and pregnant women, umbilical serum EGF levels and umbilical cord blood serum and serum levels of EGF between the differences. Results Compared with the control group, there was no significant difference in LAMP group amniotic fluid, pregnant women and umbilical vein serum EGF (P> 0.2). Compared with the control group, the EGF concentration of amniotic fluid in IUGR group was significantly lower, and the EGF concentration in pregnant women and umbilical vein was significantly (P <0.05). Compared with LGA group, the concentration of EGF in serum of umbilical vein of IUGR group was significantly increased (P <0.05), while there was no significant difference in EGF concentration between amniotic fluid and pregnant women (P> 0.05). Umbilical artery and venous serum EGF concentration, the difference was not significant (P> 0.1). Conclusions Epinephrine, pregnant women and fetus may have different sources of EGF; EGF may be related to the occurrence of IUGR.