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哌唑嗪(PZ)与肼苯哒嗪和硝酸盐作用不同,它具有β—肾上腺素能受体阻滞作用,对静脉和动脉都具强有力的作用,使心前负荷和后负荷均减低。作者对12例严重慢性充血性心衰用地高辛和利尿剂治疗无效的病人,进行PZ口服以观察其远期疗效。患者口服PZ,一日三次,首次于晚上服0.5mg逐渐增量。两周内根据血压下降的情况和临床反应调整至最大剂量(3—20mg/日),地高辛和利尿剂的用量不变。在用药前和用药后的第
Prazosin (PZ) is different from hydralazine and nitrate in that it has a block of β-adrenergic receptors and has a potent effect on both veins and arteries, reducing both pre-load and post-load . The author of 12 cases of severe chronic congestive heart failure with digoxin and diuretic therapy in patients with PZ orally to observe its long-term efficacy. Oral PZ patients, three times a day, for the first time in the evening serving 0.5mg incremental. Two weeks according to the blood pressure drop and clinical response to the maximum dose (3-20mg / day), digoxin and diuretic dosage unchanged. Before and after medication