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应用蝮蛇抗栓酶治疗肾病综合征患者21例，进行治疗前后对照观察。结果显示：治疗后血纤维蛋白原、血小板最大聚集率有显著下降（P＜0．01），但24h尿蛋白、血肌酐、尿素氮、胆固醇、甘油三酯及低密度脂蛋白较治疗前无明显变化（P＞0．05）。同时发现治疗后血浆6酮前列腺素显著增高（P＜0．05）、血栓素B2稍有降低（P＞0．05），血栓素B2／6酮前列腺素比值有显著降低；血浆过氧化脂质也有显著降低（P＜0．05）。表明蝮蛇抗栓酶能降低血纤维蛋白原和血小板聚集，改善高凝状态，防止血栓形成，机理可能与其抑制脂质过氧化，减少血管内皮损害，增高前列腺素I2合成有关。
21 cases of nephrotic syndrome were treated with Agkistrodon antithrombin, and were observed before and after treatment. The results showed that the maximum aggregation rate of fibrinogen and platelet decreased significantly after treatment (P <0.01), but the levels of 24h urinary protein, serum creatinine, urea nitrogen, cholesterol, triglyceride and low density lipoprotein Significant changes (P> 0.05). At the same time, the plasma 6-ketoprostaglandin significantly increased (P <0.05), the thromboxane B2 decreased slightly (P> 0.05) and the B2 / 6 ketoprostone ratio decreased significantly. The plasma lipid peroxidation The quality was also significantly lower (P <0.05). The results showed that viper snake antithrombin can reduce fibrinogen and platelet aggregation, improve hypercoagulable state and prevent thrombosis, the mechanism may be related to its inhibition of lipid peroxidation, reduce vascular endothelial damage and increase prostaglandin I2 synthesis.