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目的:通过研究补肝益肾清脂饮对实验性高脂血症大鼠的影响,观察其对血脂的影响。方法:选取Wistar大鼠,雄性,体重(180±20)g,将其随机分为6组,10只/组,分别为空白对照组,高脂模型组,清脂饮大、中、小剂量组,血脂康组。空白组正常饮食;高脂模型组喂食高脂饲料;药物组除高脂饮食外,每日给予相应的药物灌胃;各组每鼠每日喂20g,连续喂食6周。干预6周后,检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(H D L-C)、低密度脂蛋白胆固醇(L D L-C)含量。结果:补肝益肾清脂饮对高脂血症大鼠血清TC、TG、LDL-C水平(P<0.05或P<0.01)有降低作用,并能升高HDL-C水平(P<0.05)。结论:补肝益肾清脂饮对高脂血症大鼠具有调节血脂的作用。
Objective: To study the effects of Bugan Yishen Qingzhi Yin on experimental hyperlipidemic rats, and observe its effects on blood lipid. Methods: Male Wistar rats weighing 180 ± 20 g were randomly divided into 6 groups (10 rats / group): blank control group, high fat model group, Qingzhi Yin large, middle and small dose Group, Xuezhikang group. The rats in the blank group were given normal diet. The high-fat model group was fed with high-fat diet. In addition to the high-fat diet, the rats in the high-fat diet group were given the corresponding drugs orally daily. Each group was fed with 20g daily for 6 weeks. Six weeks after the intervention, serum TC, TG, HDL-C, and LDL-C were measured. Results: Bugan Yishenqingzhi Decoction could reduce serum TC, TG and LDL-C levels (P <0.05 or P <0.01) and increase HDL-C levels in hyperlipidemic rats (P <0.05 ). Conclusion: Bugan Yishen Qingzhi Decoction can regulate blood lipid in hyperlipidemic rats.