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目的 :观察湖沼型血吸虫病流行区用蒿甲醚预防日本血吸虫感染的效果。方法 :1996年4— 11月 ,选择安徽省贵池市唐田乡 2个村为试点 ,选择 6岁— 65岁村民随机配对分为蒿甲醚组和对照组。在服蒿甲醚前 2 0 d,经粪检查病 ,并服单剂吡喹酮 4 0 mg/kg— 50 mg/kg治疗。于 5月下旬口服第 1剂蒿甲醚 6mg/kg,以后每半个月服 1次 ,共 10次 ,对照组口服相同剂型的安慰剂。结果 :口服蒿甲醚 4 33例粪检全部阴性 ,无急性血吸虫病发生 ;对照组 4 52人的粪检感染率为8.9% ,并发生 1例急性血吸虫病。口服蒿甲醚对肝、肾功能、网织红细胞和心电图未见明显异常。结论 :在整个传播季节每半个月口服 1次蒿甲醚 6mg/kg,对湖沼型重度血吸虫病流行区人群有较好的预防作用 ,为制定防治湖区血吸虫病策略提供一种新的措施。
Objective: To observe the effect of artemether on the prevention of Schistosoma japonicum infection in schistosomiasis endemic areas. Methods: From November to November 1996, two villages from Tangtian Township, Guichi, Anhui Province were selected as experimental groups. Villagers aged 6 - 65 were randomly assigned to artemether and control groups. On the 20th day before taking artemether, the patients were diagnosed by fecal examination and treated with a single dose of praziquantel 40 mg / kg-50 mg / kg. The first dose of artemether 6mg / kg was given orally in late May, and once every two weeks for 10 times. The control group was given the same dosage of placebo. Results: 433 cases of oral administration of artemether were negative and no acute schistosomiasis was found. In the control group, 524 cases of fecal infection were found to be 8.9%, and 1 case of acute schistosomiasis occurred. Oral artemether on the liver, kidney function, reticulocyte and ECG showed no significant abnormalities. Conclusion: Artemether 6 mg / kg given orally once every half a month during the whole transmission season has a good preventive effect on the population with severe schistosomiasis prevalence in lakes and marshes and provides a new measure for the prevention and control of schistosomiasis in the lake area.