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目的 探讨过敏性紫癜 (HSP)患儿肾损害早期诊断的实验室指标与肾活检病理改变的相关性。方法 对2 3例多次尿常规检查正常的 HSP患儿通过检测尿微量蛋白 (Ig G、 MA、 TRF、 α1 - MG、 β2 - MG)及尿酶 (NAG、 γ-GT)的含量 ,且同时行肾活检病理检查。结果 2 3例多次尿常规检查正常的 HSP患儿。肾活检病理出现异常者占95.7% ,尿高分子量蛋白 (Ig G、 MA、 TRF)检测异常者占 60 .9%。与肾活检病理比较 ,差异有显著性 (P<0 .0 5)。尿低分子量蛋白 (α1 - MG、β2 - MG)检测异常者占 65.2 % ,与肾活检病理比较差异有显著性 (P<0 .0 5) ;尿酶 (NAG、γ-GT)检测异常者占 56.5% ,与肾活检病理比较 ,差异有显著性 (P<0 .0 1 ) ;尿微量蛋白 (Ig G、MA、 TRF、 α1 - MG、β2 - MG) 5项指标综合检测异常者占 78.30 %。与肾活检病理比较 ,差异无显著性 (P>0 .0 5) ;尿微量蛋白 (Ig G、 MA、TRF、α1 - MG、β2 - MG)及尿酶 (NAG、γ- GT) 7项指标综合检测异常者占 87% ,与肾活检病理比较 ,差异无显著性(P>0 .0 5)。结论 肾活检病理是早期诊断 HSP肾损害的金指标。尿微量蛋白、尿酶是早期诊断 HSP肾损害的良好指标。尿微量蛋白 (Ig G、MA、 TRF、 α1 - MG、 β2 - MG) 5项指标综合检测 ,或尿微量蛋白 (Ig G、
Objective To investigate the correlation between laboratory indexes of early diagnosis of renal damage and pathological changes of renal biopsy in children with Henoch-Schonlein purpura (HSP). Methods The levels of urinary microalbumin (Ig G, MA, TRF, α1 - MG, β2 - MG) and urease (NAG, γ - GT) were detected in 23 children with multiple urinalysis. At the same time renal biopsy pathology. Results 23 cases of urinary routine examination of many children with normal HSP. The abnormal renal biopsy accounted for 95.7%, urinary high molecular weight protein (Ig G, MA, TRF) detected abnormalities accounted for 60.9%. Compared with the renal biopsy, the difference was significant (P <0.05). Urine low molecular weight protein (α1 - MG, β2 - MG) detected abnormalities accounted for 65.2%, and renal biopsy showed significant difference (P <0.05); urease (NAG, γ- Accounting for 56.5%, which were significantly different from those of renal biopsy (P <0.01); those with abnormal detection of 5 microalbuminuria (Ig G, MA, TRF, α1 - MG and β2 - MG) 78.30%. There was no significant difference between the two groups (P> 0.05) and the pathological changes of renal biopsy (P> 0.05). There were 7 urinary microalbuminuria (IgG, MA, TRF, α1 - MG and β2 - MG) The index of comprehensive detection of abnormal 87%, compared with the renal biopsy, the difference was not significant (P> 0.05). Conclusion Kidney biopsy is a gold index for the early diagnosis of HSP renal damage. Urinary microalbuminuria, urease is a good indicator of early diagnosis of renal damage in HSP. Urine microalbumin (Ig G, MA, TRF, α1 - MG, β2 - MG) comprehensive detection of five indicators, or urine microalbumin (Ig G,